A Study of the Prophylactic Effectiveness of Several
نویسنده
چکیده
In 1931 and 1933, James (1 to 3) reported the first work on the prophylactic activity of the standard antimalarial agents, quinine, quinacrine (atabrine), and pamaquin (plasmochin), in Plasmodium vivax malaria under controlled conditions. He demonstrated that neither quinine nor quinacrine, given as prophylactic agents in therapeutic doses, prevented malarial infection. Extensive experience in the field (4 to 6) has corroborated this finding. James (3) also reported that when pamaquin was given in amounts approaching the maximum tolerated dose for eight days, starting the day before sporozoite inoculation, none of the subjects developed malaria. Smaller doses protected only a few of the subjects. However, in 1944, Feldman, Packer, et al. (7),
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تاریخ انتشار 2013